During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …

Background Normal pregnancy relies on a careful balance between immune tolerance and
suppression. It is known that strict regulation of maternal immune function, in addition to …

Background The increased potential for negative pregnancy outcomes in both extremes of
reproductive age is a well-debated argument. The aim of this study was to analyze the …

Progesterone suppresses uterine contractility acting through its receptors (PRA/B). The
mechanism by which human labour is initiated in the presence of elevated circulating …

Every year, 11% of infants are born preterm with significant health consequences, with the
vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) …

After several decades of research, we now have evidence that at least six interventions are
suitable for immediate use in contemporary clinical practice within high-resource settings …

The hypothalamic-pituitary-adrenocortical (HPA) axis is a major neuroendocrine pathway
that modulates the stress response. The glucocorticoid, cortisol, is the principal end product …

Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …

Abstract Background. Protease inhibitor (PI)–based combination antiretroviral therapy
(cART) is administered during pregnancy to prevent perinatal human immunodeficiency …

Objective. To conduct systematic analyses to evaluate the efficacy of progesterone therapy
for the prevention of miscarriages in pregnant women experiencing threatened abortion …