Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

The modern era of multiple sclerosis (MS) treatment began 25 years ago, with the approval
of IFNβ and glatiramer acetate for the treatment of relapsing–remitting MS. Ten years later …

Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …

Circulating cytokines and growth factors are regulators of inflammation and have been
implicated in autoimmune and metabolic diseases. In this genome-wide association study …

Multiple sclerosis (MS) has been thought to be a complex and indecipherable disease, and
poorly understood with regards to aetiology. Here, we suggest an emphatically positive view …

Interleukin-2 (IL-2) is integral to immune system regulation. Its opposing immunostimulatory
and immunosuppressive actions make it an attractive therapeutic target for cancer and …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating central nervous system
disease that typically strikes young adults, especially women. The pathobiology of MS …

Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular
synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and …

Background Multiple sclerosis (MS) is a chronic and autoimmune disease of the central
nervous system (CNS), mainly characterized by inflammatory demyelination, which …