Do carbon nanotubes and asbestos fibers exhibit common toxicity mechanisms?

SS Gupta, KP Singh, S Gupta, M Dusinska, Q Rahman - Nanomaterials, 2022 - mdpi.com
During the last two decades several nanoscale materials were engineered for industrial and
medical applications. Among them carbon nanotubes (CNTs) are the most exploited …

[PDF][PDF] Mitogen-activated protein kinase pathways in redox signaling

M Torres - Front Biosci, 2003 - article.imrpress.com
[Frontiers in Bioscience 8, d369-391, January 1, 2003] 369 MITOGEN-ACTIVATED PROTEIN
KINASE PATHWAYS IN REDOX SIGNALING Martine Page 1 [Frontiers in Bioscience 8 …

Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex

Z Gao, D Hwang, F Bataille, M Lefevre, D York… - Journal of Biological …, 2002 - ASBMB
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus.
One mechanism mediating insulin resistance may involve the phosphorylation of serine …

p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice

G Ramesh, WB Reeves - American Journal of Physiology …, 2005 - journals.physiology.org
Cisplatin is an important chemotherapeutic agent but can cause acute renal injury. Part of
this acute renal injury is mediated through tumor necrosis factor-α (TNF-α). The pathway …

Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species

V Castranova - Free radical biology and medicine, 2004 - Elsevier
Occupational exposure to crystalline silica has been linked to pulmonary fibrosis and lung
cancer. Surface properties of crystalline silica are critical to the production of oxidant …

Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor α promoter in vivo

V Staniforth, SY Wang, LF Shyur, NS Yang - Journal of Biological Chemistry, 2004 - ASBMB
Tumor necrosis factor α (TNF-α) contributes to the pathogenesis of both acute and chronic
inflammatory diseases and has been a target for the development of new anti-inflammatory …

Induction of tumor necrosis factor‐α (TNF‐α) by interleukin‐12 p40 monomer and homodimer in microglia and macrophages

M Jana, S Dasgupta, RN Saha, X Liu… - Journal of …, 2003 - Wiley Online Library
The present study was undertaken to explore the role of interleukin‐12 (IL‐12) p40 in the
expression of TNF‐α in microglia. Interestingly, we have found that IL‐12 p70, p402 (the p40 …

Polysaccharides from Dendrobium huoshanense stems alleviates lung inflammation in cigarette smoke-induced mice

JC Ge, XQ Zha, CY Nie, NJ Yu, QM Li, DY Peng… - Carbohydrate …, 2018 - Elsevier
The present work investigated the inhibitory activity of the polysaccharide from cultivated
Dendrobium huoshanense (cDHP) on lung inflammation in cigarette smoke (CS)-induced …

Inhibition of transcriptional activity of c-JUN by SIRT1

Z Gao, J Ye - Biochemical and biophysical research communications, 2008 - Elsevier
c-JUN is a major component of heterodimer transcription factor AP-1 (Activator Protein-1)
that activates gene transcription in cell proliferation, inflammation and stress responses …

Endotoxin and cisplatin synergistically stimulate TNF-α production by renal epithelial cells

G Ramesh, SR Kimball, LS Jefferson… - American Journal of …, 2007 - journals.physiology.org
Acute renal failure often occurs in the clinical setting of multiple renal insults. Tumor necrosis
factor-α (TNF-α) has been implicated in the pathogenesis of cisplatin nephrotoxicity …