Synthetic product-based approach toward potential antileishmanial drug development

R Pal, G Teli, MJ Akhtar, GSP Matada - European Journal of Medicinal …, 2024 - Elsevier
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …

Synthetic and medicinal perspective of antileishmanial agents: an overview

S Pawar, MK Kumawat, M Kundu, K Kumar - Journal of Molecular Structure, 2023 - Elsevier
Leishmaniasis is one of the most common neglected tropical diseases (NTD), and is
originated in over 98 countries, affecting about 12 million people every year, which is …

Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments

SM Khirallah, HMM Ramadan, A Shawky, SH Qahl… - Molecules, 2022 - mdpi.com
Inflammation is the main cause of several autoimmune diseases, including type I diabetes,
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …

The cytotoxic and anti-leishmanial activity of Oregano (Origanum vulgare) essential oil: An in vitro, in vivo, and in silico study

F Tomiotto-Pellissier, BT da Silva Bortoleti… - Industrial Crops and …, 2022 - Elsevier
This study was aimed at investigating the leishmanicidal and immunomodulatory of oregano
essential oil (OEO) from Origanum vulgare on experimental Leishmania amazonensis …

Novel imidazolium-thiohydantoin hybrids and their Mn (III) complexes for antimicrobial and anti-liver cancer applications

LA Ismail, R Zakaria, EM Hassan, MY Alfaifi, AA Shati… - RSC …, 2022 - pubs.rsc.org
We present the effective synthesis and structural characterization of three novel imidazolium-
thiohydantoin ligands (IMTHs, 5a–c) and their Mn (III) complexes (Mn (III) IMTHs, 6a–c) in …

Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis

KM de Santiago-Silva, BTS Bortoleti, LN Oliveira… - Antibiotics, 2022 - mdpi.com
Leishmaniasis is a neglected tropical disease caused by Leishmania species. Available
therapeutic options have several limitations. The drive to develop new, more potent, and …

[HTML][HTML] Models for cytotoxicity screening of antileishmanial drugs: what has been done so far?

MBC Brioschi, EM Coser, AC Coelho… - International Journal of …, 2022 - Elsevier
A growing number of studies have demonstrated the in vitro potential of an impressive
number of antileishmanial candidates in the past years. However, the lack of uniformity …

In silico approach identified benzoylguanidines as SARS-CoV-2 main protease (Mpro) potential inhibitors

KM Santiago-Silva, P Camargo… - Journal of …, 2023 - Taylor & Francis
Abstract The coronavirus disease-2019 (COVID-19) pandemic, caused by the novel
coronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), became the …

In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition

PG Camargo, HT Suzukawa, PML Pereira, ML Silva… - Scientific Reports, 2025 - nature.com
This work investigates the anti-trypanosomal activities of ten thiohydantoin derivatives
against the parasite Trypanosoma cruzi. Compounds with aliphatic chains (THD1, THD3 …

Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors

PG Camargo, CR Dos Santos, M Girão Albuquerque… - Scientific Reports, 2024 - nature.com
Leishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting
millions of people, mainly in tropical countries, due to poor social conditions and low …