Dietary regulation of gut-brain axis in Alzheimer's disease: Importance of microbiota metabolites

DM Frausto, CB Forsyth, A Keshavarzian… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease that impacts 45 million people
worldwide and is ranked as the 6th top cause of death among all adults by the Centers for …

[HTML][HTML] Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

RJ Johnson, DR Tolan, D Bredesen, M Nagel… - The American Journal of …, 2023 - Elsevier
An important aspect of survival is to assure enough food, water, and oxygen. Here, we
describe a recently discovered response that favors survival in times of scarcity, and it is …

Sweet but bitter: Focus on fructose impact on brain function in rodent models

MS Spagnuolo, S Iossa, L Cigliano - Nutrients, 2020 - mdpi.com
Fructose consumption has drastically increased during the last decades due to the extensive
commercial use of high-fructose corn syrup as a sweetener for beverages, snacks and …

High fructose diet-induced metabolic syndrome: pathophysiological mechanism and treatment by traditional Chinese medicine

Y Pan, LD Kong - Pharmacological research, 2018 - Elsevier
Fructose is a natural monosaccharide broadly used in modern society. Over the past few
decades, epidemiological studies have demonstrated that high fructose intake is an …

Empagliflozin nanoparticles attenuates type2 diabetes induced cognitive impairment via oxidative stress and inflammatory pathway in high fructose diet induced …

T Khan, S Khan, M Akhtar, J Ali, AK Najmi - Neurochemistry International, 2021 - Elsevier
There is snowballing evidence that type 2 diabetes (T2D) predisposes to
neuropathophysiological alterations including oxidative stress and triggered inflammatory …

Mechanisms affecting brain remodeling in depression: do all roads lead to impaired fibrinolysis?

S Hoirisch-Clapauch - Molecular Psychiatry, 2022 - nature.com
Fibrinolysis occurs when plasminogen activators, such as tissue plasminogen activator
(tPA), convert plasminogen to plasmin, which dissolves the fibrin clot. The proteolytic activity …

Neural mechanisms underlying the role of fructose in overfeeding

MA Payant, MJ Chee - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Fructose consumption has been linked with metabolic syndrome and obesity. Fructose-
based sweeteners like high fructose corn syrup taste sweeter, improve food palatability, and …

Breakfast: A crucial meal for adolescents' cognitive performance according to their nutritional status. The cogni-action project

H Peña-Jorquera, V Campos-Núñez, KP Sadarangani… - Nutrients, 2021 - mdpi.com
This study aimed to determine whether pupils who have breakfast just before a cognitive
demand, do not regularly skip breakfast, and consume a high-quality breakfast present …

Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence

I Kageyama, H Yamada, E Munetsuna, M Yamazaki… - PLoS …, 2022 - journals.plos.org
Consumption of fructose-containing beverages such as high-fructose corn syrup (HFCS) is
increasing, raising concerns about the negative effects of excessive fructose intake. A recent …

Glucose, fructose, and urate transporters in the choroid plexus epithelium

Y Chiba, R Murakami, K Matsumoto… - International Journal of …, 2020 - mdpi.com
The choroid plexus plays a central role in the regulation of the microenvironment of the
central nervous system by secreting the majority of the cerebrospinal fluid and controlling its …