Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

BACKGROUND Different technologies, such as quantitative real-time PCR or microarrays,
have been developed to measure microRNA (miRNA) expression levels. Quantification of …

Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes:
C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA …

Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

The discovery of miRNAs as important regulatory agents for gene expression has expanded
the therapeutic opportunities for oligonucleotides. In contrast to siRNA, miRNA-targeted …

While the role of small non-coding RNAs, such as miRNAs, in apoptosis control is well
established, long non-coding RNAs (lncRNAs) have received less attention. Growth Arrest …

Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous
elements in the production of the protein synthesis machinery of the cell. Recently, however …

Background Gastric cancer is the second leading cause of cancer death and remains a
major clinical challenge due to poor prognosis and limited treatment options. Long …

It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental
biological processes and, consequently, that their dysregulation may contribute to major …