The development of so-called immune checkpoint inhibitors (ICIs), which target specific
molecular processes of tumour growth, has had a transformative effect on cancer treatment …

The use of multi‐scale mathematical and computational models to study complex biological
processes is becoming increasingly productive. Multi‐scale models span a range of spatial …

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways
can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives …

People with spinal cord injury (SCI) are predisposed to pressure ulcers (PU). PU remain a
significant burden in cost of care and quality of life despite improved mechanistic …

Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced
liver injury often assume that the biomarker is released passively from dying cells. However …

A crisis continues to brew within the pharmaceutical research and development (R&D)
enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic …

Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in
humans. A precondition for improved strategies to disrupt and/or reverse the damage is a …

Background Currently, most biomedical models exist in isolation. It is often difficult to reuse
or integrate models or their components, in part because they are not modular. Modular …

In this era of tremendous technological capabilities and increased focus on improving
clinical outcomes, decreasing costs, and increasing precision, there is a need for a more …

Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in
mice often serves as a model for drug-induced liver injury in humans. By specifying that …