Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs

G Pezzulo, M Levin - Integrative Biology, 2015 - academic.oup.com
A major goal of regenerative medicine and bioengineering is the regeneration of complex
organs, such as limbs, and the capability to create artificial constructs (so-called biobots) …

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex

DJ Di Bella, N Domínguez-Iturza, JR Brown, P Arlotta - Neuron, 2024 - cell.com
Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

[HTML][HTML] Long-term, stochastic editing of regenerative anatomy via targeting endogenous bioelectric gradients

F Durant, J Morokuma, C Fields, K Williams… - Biophysical journal, 2017 - cell.com
We show that regenerating planarians' normal anterior-posterior pattern can be permanently
rewritten by a brief perturbation of endogenous bioelectrical networks. Temporary …

Endogenous bioelectrics in development, cancer, and regeneration: drugs and bioelectronic devices as electroceuticals for regenerative medicine

M Levin, J Selberg, M Rolandi - Iscience, 2019 - cell.com
A major frontier in the post-genomic era is the investigation of the control of coordinated
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …

Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities

JL Whited, M Levin - Current opinion in genetics & development, 2019 - Elsevier
Cell-to-cell communication is a cornerstone of multicellular existence. The ancient
mechanism of sharing information between cells using the conductance of ions across cell …

Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte

JS Yang, W Qi, R Farias-Pereira, S Choi… - Food and chemical …, 2019 - Elsevier
Recent studies have reported the positive association between exposure to insecticides and
increased risk of obesity and type 2 diabetes, which are closely associated with non …

A high level of TGF-B1 promotes endometriosis development via cell migration, adhesiveness, colonization, and invasiveness

UK Soni, SB Chadchan, V Kumar, V Ubba… - Biology of …, 2019 - academic.oup.com
Endometriosis is a prevalent gynecological disorder that eventually gives rise to painful
invasive lesions. Increased levels of transforming growth factor-beta 1 (TGF-B1) have been …

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

K Karkali, SW Vernon, RA Baines, G Panayotou… - Nature …, 2023 - nature.com
Central nervous system organogenesis is a complex process that obeys precise
architectural rules. The impact that nervous system architecture may have on its functionality …

Endogenous two-photon excited fluorescence imaging characterizes neuron and astrocyte metabolic responses to manganese toxicity

E Stuntz, Y Gong, D Sood, V Liaudanskaya, D Pouli… - Scientific Reports, 2017 - nature.com
As neurodegenerative conditions are increasingly linked to mitochondrial dysfunction,
methods for studying brain cell metabolism at high spatial resolution are needed to elucidate …

Aging as a morphostasis defect: a developmental bioelectricity perspective

L Pio-Lopez, M Levin - 2024 - osf.io
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. We argue here that the …