Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

[HTML][HTML] Pre-RNA splicing in metabolic homeostasis and liver disease

AM Jobbins, S Yu, HAB Paterson, H Maude… - Trends in Endocrinology …, 2023 - cell.com
The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …

[HTML][HTML] CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer

J Zhang, S Chen, S Wei, S Cheng, R Shi, R Zhao… - Redox Biology, 2022 - Elsevier
Endometrial cancer (EC) is one of the most common gynecological cancers. Ferroptosis is a
newly identified form of cell death characterized by iron-dependent lipid peroxide …

DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma

B Zhu, JJ Chen, Y Feng, JL Yang, H Huang… - Journal of Experimental …, 2021 - Springer
Background Angiogenesis plays an important role in the occurrence, development and
metastasis of hepatocellular carcinoma (HCC). According to previous studies, miR-378a …

Constitutively active androgen receptor in Hepatocellular Carcinoma

EJ Montgomery, E Xing, MJ Campbell, PK Li… - International journal of …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the predominant type of liver cancer and a leading
cause of cancer-related death globally. It is also a sexually dimorphic disease with a male …

PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing

JL López-Cánovas, N Hermán-Sánchez… - … & Molecular Medicine, 2023 - nature.com
Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing
machinery components (spliceosome and splicing factors) and aberrant expression of …

Alternative RNA splicing in fatty liver disease

P Wu, M Zhang, NJG Webster - Frontiers in endocrinology, 2021 - frontiersin.org
Alternative RNA splicing is a process by which introns are removed and exons are
assembled to construct different RNA transcript isoforms from a single pre-mRNA. Previous …

Circular RNA hsa_circ_0062682 binds to YBX1 and promotes oncogenesis in Hepatocellular Carcinoma

R Razpotnik, R Vidmar, M Fonović, D Rozman… - Cancers, 2022 - mdpi.com
Simple Summary Circular RNA (circRNA) have a role in carcinogenesis in different cancers,
also in hepatocellular carcinoma (HCC). The transcriptome analyses of HCC tumours …

Beyond prostate cancer: An androgen receptor splice variant expression in multiple malignancies, non-cancer pathologies, and development

KD Katleba, PM Ghosh, M Mudryj - Biomedicines, 2023 - mdpi.com
Multiple studies have demonstrated the importance of androgen receptor (AR) splice
variants (SVs) in the progression of prostate cancer to the castration-resistant phenotype …

Immunological significance of prognostic alternative splicing signature in hepatocellular carcinoma

Q Xu, H Xu, R Deng, N Li, R Mu, Z Qi, Y Shen… - Cancer cell …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high
mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which …