Protein folding in the endoplasmic reticulum (ER) is an essential cell function. To safeguard
this process in the face of environmental threats and internal stressors, cells mount an …

The normal development and function of photoreceptors is essential for eye health and
visual acuity in vertebrates. Mutations in genes encoding proteins involved in photoreceptor …

Rheumatic diseases represent a heterogeneous group of inflammatory conditions, many of
which involve chronic activation of both innate and adaptive immune responses by multiple …

Introduction This randomized, controlled study on patients with polymyositis or
dermatomyositis was based on three hypotheses: patients display impaired endurance due …

Objective Endurance exercise demonstrates beneficial effects in polymyositis/
dermatomyositis (PM/DM); however, the molecular effects of exercise on skeletal muscle are …

Sarcopenia is associated with adverse health outcomes. This study investigated whether
skeletal muscle gene expression was associated with lean mass and grip strength in …

Our appreciation of the role of endoplasmic reticulum (ER) stress pathways in both skeletal
muscle homeostasis and the progression of muscle diseases is gaining momentum. This …

As antigen-presenting cells (APC), B cells exert a variety of immune regulatory functions
mainly by presenting antigens, triggering immune response, and producing antibodies for …

Background: Edasalonexent is an orally administered small molecule designed to inhibit NF-
κB, which is activated from infancy in Duchenne muscular dystrophy and is central to …

Background/Aims: The primary objective of this study was to investigate the role of miR-146a
in inducing the inflammatory infiltration of macrophages in polymyositis/dermatomyositis …