The Vav family proteins (Vav1, Vav2, Vav3) are cytoplasmic guanine nucleotide exchange
factors (GEFs) for Rho-family GTPases. T-cell antigen receptor (TCR) signalling results in …

The Vav family is a group of tyrosine phosphorylation-regulated signal transduction
molecules hierarchically located downstream of protein tyrosine kinases. The main function …

The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface
extensions (lamellipodia) required for cell migration/invasion during cancer metastasis. Rac …

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin
lymphomas frequently associated with poor prognosis and for which genetic mechanisms of …

Vav guanine nucleotide exchange factors (GEFs) have been implicated in cell adhesion by
integrin and immune response receptors through the regulation of Rho GTPases. Here, we …

Herein, we show that the hematopoietic-specific GEF VAV1 is ectopically expressed in
primary pancreatic adenocarcinomas due to demethylation of the gene promoter …

Activation of Akt by growth factors is a multistep process. Here, we provide evidence that
tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 …

The diffuse B-cell lymphoma (Dbl) family of the guanine nucleotide exchange factors is a
direct activator of the Rho family proteins. The Rho family proteins are involved in almost …

Actin reorganization at the immunological synapse is required for the amplification and
generation of a functional immune response. Using small interfering RNA, we show here …

Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and
signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the …