Radiochemistry: a hot field with opportunities for cool chemistry

GD Bowden, PJH Scott, E Boros - ACS Central Science, 2023 - ACS Publications
Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic
radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to …

Synthesis of radioiodinated compounds. Classical approaches and achievements of recent years

SA Petrov, MS Yusubov, EK Beloglazkina… - International Journal of …, 2022 - mdpi.com
This review demonstrates the progress in the synthesis of radioiodinated compounds over
the past decade. The possibilities and limitations of radiopharmaceuticals with different …

Albumin-binding PSMA ligands: optimization of the tissue distribution profile

M Benešová, CA Umbricht, R Schibli… - Molecular …, 2018 - ACS Publications
The prostate-specific membrane antigen (PSMA) has emerged as an attractive prostate
cancer associated target for radiotheragnostic application using PSMA-specific radioligands …

Rapid precision targeting of nanoparticles to lung via caveolae pumping system in endothelium

TR Nayak, A Chrastina, J Valencia… - Nature …, 2024 - nature.com
Modern medicine seeks precision targeting, imaging and therapy to maximize efficacy and
avoid toxicities. Nanoparticles (NPs) have tremendous yet unmet clinical potential to carry …

Radioiodine based biomedical carriers for cancer theranostics

J Guo, H Xiong, H Liu, T Zhang, X Sun - Coordination Chemistry Reviews, 2023 - Elsevier
Theranostics, a promising modern concept combining diagnostic capabilities and
therapeutic effects, has been used for optimizing and personalizing the treatment of many …

[HTML][HTML] The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists

X Yi, E Tran, JO Odiba, CX Qin, RH Ritchie… - European journal of …, 2024 - Elsevier
Formyl peptide receptors (FPRs) comprise a class of chemoattractant pattern recognition
receptors, for which several physiological functions like host-defences, as well as the …

Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability

H Suzuki, Y Kaizuka, M Tatsuta, H Tanaka… - Journal of Medicinal …, 2021 - ACS Publications
The high in vivo stability of 2, 2-dihydroxymethyl-3-[18F] fluoropropyl-2-nitroimidazole ([18F]
DiFA) prompted us to evaluate neopentyl as a scaffold to prepare a radiotheranostic system …

Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis

F Krutzek, K Kopka, S Stadlbauer - Pharmaceuticals, 2022 - mdpi.com
Immune checkpoint inhibitor (ICI) therapy has emerged as a major treatment option for a
variety of cancers. Among the immune checkpoints addressed, the programmed death …

Recent advances in synthetic methods for radioiodination

E Dubost, H McErlain, V Babin… - The Journal of …, 2020 - ACS Publications
Organic compounds bearing radioisotopes of iodine are widely used for biological research,
diagnostic imaging, and radiotherapy. Early reported synthetic methods for the incorporation …

Dipeptide-Derived Alkynes as Potent and Selective Irreversible Inhibitors of Cysteine Cathepsins

L Behring, G Ruiz-Gómez, C Trapp… - Journal of medicinal …, 2023 - ACS Publications
The potential of designing irreversible alkyne-based inhibitors of cysteine cathepsins by
isoelectronic replacement in reversibly acting potent peptide nitriles was explored. The …