Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
Genetic variants associated with resilience in human and animal studies
Resilience is broadly defined as the ability to maintain or regain functioning in the face of
adversity and is influenced by both environmental and genetic factors. The identification of …
adversity and is influenced by both environmental and genetic factors. The identification of …
Neuroanatomical and functional consequences of oxytocin treatment at birth in prairie voles
Birth is a critical period for the developing brain, a time when surging hormone levels help
prepare the fetal brain for the tremendous physiological changes it must accomplish upon …
prepare the fetal brain for the tremendous physiological changes it must accomplish upon …
APOE4 rat model of Alzheimer's disease: sex differences, genetic risk and diet
The strongest genetic risk factor for Alzheimer's disease (AD) is the ε4 allele of
apolipoprotein E (ApoE ε4). A high fat diet also adds to the risk of dementia and AD. In …
apolipoprotein E (ApoE ε4). A high fat diet also adds to the risk of dementia and AD. In …
Features of lipid metabolism in humanized apoe knockin rat models
Apolipoprotein E (ApoE), an essential plasma apolipoprotein, has three isoforms (E2, E3,
and E4) in humans. E2 is associated with type III hyperlipoproteinemia. E4 is the major …
and E4) in humans. E2 is associated with type III hyperlipoproteinemia. E4 is the major …
Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age
BH Lee, M Cevizci, SE Lieblich, M Ibrahim… - Brain, Behavior, and …, 2024 - Elsevier
Female sex and Apolipoprotein E (APOE) ε4 genotype are top non-modifiable risk factors for
Alzheimer's disease (AD). Although female-unique experiences like parity (pregnancy and …
Alzheimer's disease (AD). Although female-unique experiences like parity (pregnancy and …
Novel influences of sex and APOE genotype on spinal plasticity and recovery of function after spinal cord injury
LE Strattan, DRS Britsch, CM Calulot, RSJ Maggard… - eneuro, 2021 - eneuro.org
Spinal cord injuries can abolish both motor and sensory function throughout the body.
Spontaneous recovery after injury is limited and can vary substantially between individuals …
Spontaneous recovery after injury is limited and can vary substantially between individuals …
Differences in diffusion-weighted imaging and resting-state functional connectivity between two culturally distinct populations of prairie vole
Background We used the highly prosocial prairie vole to test the hypothesis that higher-
order brain structure—microarchitecture and functional connectivity (FC)—would differ …
order brain structure—microarchitecture and functional connectivity (FC)—would differ …
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities
Cerebrovascular abnormality is linked to Alzheimer's disease and related dementias
(ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction …
(ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction …
Apolipoprotein E-Genotyping and MRI Study for Alzheimer's Disease Classification: PCR-RFLP and Restricted Enzymes AfIII for RS429358 and HaeII for RS7412
The most common type of dementia in neurodegenerative diseases is Alzheimer's disease
(AD), a progressive neurological illness that causes memory loss. Neurophysiological tests …
(AD), a progressive neurological illness that causes memory loss. Neurophysiological tests …