The search for noise-induced cochlear synaptopathy in humans: Mission impossible?

N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

[HTML][HTML] Computational modeling of the human auditory periphery: Auditory-nerve responses, evoked potentials and hearing loss

S Verhulst, A Altoe, V Vasilkov - Hearing research, 2018 - Elsevier
Abstract Models of the human auditory periphery range from very basic functional
descriptions of auditory filtering to detailed computational models of cochlear mechanics …

Hidden hearing loss? No effect of common recreational noise exposure on cochlear nerve response amplitude in humans

SK Grinn, KB Wiseman, JA Baker… - Frontiers in …, 2017 - frontiersin.org
This study tested hypothesized relationships between noise exposure and auditory deficits.
Both retrospective assessment of potential associations between noise exposure history and …

Loud music exposure and cochlear synaptopathy in young adults: Isolated auditory brainstem response effects but no perceptual consequences

JH Grose, E Buss, JW Hall Iii - Trends in hearing, 2017 - journals.sagepub.com
The purpose of this study was to test the hypothesis that listeners with frequent exposure to
loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear …

Subcortical responses to music and speech are alike while cortical responses diverge

T Shan, MS Cappelloni, RK Maddox - Scientific Reports, 2024 - nature.com
Music and speech are encountered daily and are unique to human beings. Both are
transformed by the auditory pathway from an initial acoustical encoding to higher level …

Hidden hearing loss: a disorder with multiple etiologies and mechanisms

DC Kohrman, G Wan… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to
affect auditory neural processing and hearing acuity in subjects with normal audiometric …

[HTML][HTML] Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

H Guest, KJ Munro, G Prendergast, RE Millman… - Hearing research, 2018 - Elsevier
In rodents, noise exposure can destroy synapses between inner hair cells and auditory
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced …

Effects of noise exposure on auditory brainstem response and speech-in-noise tasks: A review of the literature

CG Le Prell - International journal of audiology, 2019 - Taylor & Francis
Objective: Short-term noise exposure that induces transient changes in thresholds has
induced permanent cochlear synaptopathy in multiple species. Here, the literature was …

Evidence for age-related cochlear synaptopathy in humans unconnected to speech-in-noise intelligibility deficits

PT Johannesen, BC Buzo, EA Lopez-Poveda - Hearing research, 2019 - Elsevier
Cochlear synaptopathy (or the loss of primary auditory synapses) remains a subclinical
condition of uncertain prevalence. Here, we investigate whether it affects humans and …

Effectiveness of auditory measures for detecting hidden hearing loss and/or cochlear synaptopathy: a systematic review

CM Barbee, JA James, JH Park, EM Smith… - Seminars in …, 2018 - thieme-connect.com
Standard audiometric evaluations are not sensitive enough to identify hidden hearing loss
(HHL) and/or cochlear synaptopathy (CS). Patients with either of these conditions frequently …