Spatial omics has been widely heralded as the new frontier in life sciences. This term
encompasses a wide range of techniques that promise to transform many areas of biology …

The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …

Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways
that underlie its pathological progression across brain regions remain poorly understood …

Recent advances in spatially resolved transcriptomics have enabled comprehensive
measurements of gene expression patterns while retaining the spatial context of the tissue …

The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …

Most spatial transcriptomics technologies are limited by their resolution, with spot sizes
larger than that of a single cell. Although joint analysis with single-cell RNA sequencing can …