Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune
system. Their defining property is the recognition of pathogen-derived nucleic acids through …

Human autoantibodies (auto‐Abs) neutralizing type I IFNs were first discovered in a woman
with disseminated shingles and were described by Ion Gresser from 1981 to 1984. They …

Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α,-β,
and/or-ω can underlie severe viral illnesses. We report a simple assay for the detection of …

Immunodeficiency with thymoma was described by RA Good in 1954 and is also named
after him. The syndrome is characterized by hypogammaglobulinemia associated with …

Abstract The type I IFN (IFN‐I) system is essential to limit severe viral disease in humans.
Thus, IFN‐I deficiencies are associated with serious life‐threatening infections. Remarkably …

Systemic lupus erythematosus (SLE) is a heterogeneous multisystem inflammatory disease
with wide variability in clinical manifestations. Natural arising CD4+ regulatory T cells …

Investigating the causes of individual variation in health outcomes has led to transformative
insights into human biology and advances in nearly every branch of medicine. Historically …

Autoantibodies (AABs) neutralizing type I interferons (IFN) underlie about 15% of cases of
critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity …

Type I IFNs are critical for host responses to viral infection and are also implicated in the
pathogenesis of multiple autoimmune diseases. Multiple subtypes exist within the type I IFN …

Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest
success rate (> 95%) for insect venom while a much lower chance for pollen allergy …