Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Heterotopic ossification is the formation of ectopic lamellar bone in soft tissues. It is
increasingly recognized as a complication following trauma, burns, neurologic injuries, and …

The term “frailty” is used to describe a subset of older adults who appear weaker and more
vulnerable than their age-matched counterparts, despite having similar comorbidities …

Immunology, already a discipline in its own right, has become a major part of many different
medical fields. However, its relationship to orthopedics and trauma surgery has …

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-
β) family that signal via type I and type II serine/threonine kinase receptors and intracellular …

Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO)
syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I …

Heterotopic ossification is a debilitating condition that can result from traumatic injury,
surgery, or genetic disease. We investigated the cellular origins of heterotopic …

Fibrodysplasia ossificans progressiva (FOP), a rare and disabling genetic condition
characterized by congenital malformations of the great toes and progressive heterotopic …

Inflammation in bone physiology and pathology : Current Opinion in Rheumatology
Inflammation in bone physiology and pathology : Current Opinion in Rheumatology Log in …

Heterotopic ossification (HO) is pathological bone formation characterized by ossification
within muscle, tendons, or other soft tissues. However, the cells of origin and mechanisms …