Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Alzheimer's disease (AD) is a major contributor of dementia leading to the degeneration of
neurons in the brain with major symptoms like loss of memory and learning. Many evidences …

Dementia is a neurodegenerative condition that is considered a major factor contributing to
cognitive decline that reduces independent function. Pathophysiological pathways are not …

While glia are increasingly implicated in the pathophysiology of psychiatric and
neurodegenerative disorders, available methods for imaging these cells in vivo involve …

Background Sleep deprivation (SD) leads to cognitive impairment. Neuroinflammation could
be a significant contributing factor in the same. An increase in regional brain pro …

This review analyzes the role of TNF-α and its increase in biological fluids in mild cognitive
impairment, and Alzheimer's disease (AD). The potential inhibition of TNF-α with …

The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the
pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer's …

Background Microglia reactivity is a hallmark of retinal degenerations and overwhelming
microglial responses contribute to photoreceptor death. Minocycline, a semi-synthetic …

Background Cardiovascular diseases, including heart failure, are the most common cause of
death globally. Recent studies support a high degree of comorbidity between heart failure …

Osteoarthritis (OA) is a progressive degenerative disease of the joints that is associated with
both joint injury and ageing. Here, we investigated the role of the energy sensor AMP …