Polymers and nanoparticles for statin delivery: current use and future perspectives in cardiovascular disease

A Nenna, F Nappi, D Larobina, E Verghi, M Chello… - Polymers, 2021 - mdpi.com
Atherosclerosis-related coronary artery disease (CAD) is one of the leading sources of
mortality and morbidity in the world. Primary and secondary prevention appear crucial to …

Preparation and evaluation of atorvastatin-loaded nanoemulgel on wound-healing efficacy

MA Morsy, RG Abdel-Latif, AB Nair, KN Venugopala… - Pharmaceutics, 2019 - mdpi.com
Tissue repair and wound healing are complex processes that involve inflammation,
granulation, and remodeling of the tissue. The potential of various statins including …

Improved solubility, dissolution, and oral bioavailability for atorvastatin-Pluronic® solid dispersions

MA Shaker, HM Elbadawy, MA Shaker - International Journal of …, 2020 - Elsevier
Despite the status of atorvastatin (AT) as one of the top selling statins for prophylaxis against
primary and secondary cardiovascular diseases, its limited oral absorption limits its full …

[HTML][HTML] Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique

W Dong, X Su, M Xu, M Hu, Y Sun, P Zhang - Asian journal of …, 2018 - Elsevier
Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in
conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared …

Enhancement of atorvastatin oral bioavailability via encapsulation in polymeric nanoparticles

MA Shaker, HM Elbadawy, SS Al Thagfan… - International Journal of …, 2021 - Elsevier
Despite the fact that atrovastatin (At) is being one of the bestselling statins used to prevent
complicated cardiovascular diseases, its low oral bioavailability decreases its clinical …

Significant progress in improving Atorvastatin dissolution rate: physicochemical characterization and stability assessment of self-dispersible Atorvastatin/Tween 80® …

A Rossetti, DA Real, BA Barrientos… - International Journal of …, 2024 - Elsevier
Atorvastatin (ATV) is a first-line drug for the treatment of hyperlipidemia. This drug presents
biopharmaceutical problems, partly due to its low solubility and dissolution rate. In this work …

Dissolution and bioavailability enhancement of Atorvastatin: Gelucire semi-solid binary system

MA Shaker - Journal of Drug Delivery Science and Technology, 2018 - Elsevier
Atorvastatin (Atv) is one of antihyperlipidimic drugs characterized by limited oral
bioavailability due to its low solubility-despite its high permeability-that hinders its full clinical …

Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability

R Kong, X Zhu, ES Meteleva, NE Polyakov… - Drug Delivery and …, 2018 - Springer
The aim of the present investigation was to enhance the solubility and dissolution of
atorvastatin calcium (ATV), a poorly water-soluble drug with larch polysaccharide …

Formulation of Gelucire®-Based Solid Dispersions of Atorvastatin Calcium: In Vitro Dissolution and In Vivo Bioavailability Study

BN Aldosari, AS Almurshedi, IM Alfagih… - AAPS …, 2021 - Springer
Atorvastatin (ATV) is a poorly water-soluble drug that exhibits poor oral bioavailability.
Therefore, present research was designed to develop ATV solid dispersions (SDs) to …

[PDF][PDF] Solubility and dissolution enhancement of atorvastatin calcium using solid dispersion adsorbate technique

SK Ali, EBH Al-Khedairy - Iraqi Journal of Pharmaceutical Sciences, 2019 - iasj.net
Atorvastatin (ATR) is a poorly soluble anti-hyperlipidemic drug. The drug belongs to the
class II group according to the biopharmaceutical classification system (BCS) with low …