Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …

Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage
pathway and has been reported to suppress tumorigenesis. The MTAP gene is located at …

Neuroblastoma (NB) is the most common extracranial pediatric tumor. NB patients over 18
months of age at the time of diagnosis are often in the later stages of the disease, present …

Metastases are the leading cause of treatment failure and death of patients affected by
malignant tumors, which makes them a major therapeutic target. During the last decade …

Introduction: Homozygous deletion of MTAP upregulates de novo synthesis of purine
(DNSP) and increases the proliferation of neoplastic cells. This increases the sensitivity of …

Inhibition of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by the
irreversible inhibitor α-difluoromethylornithine (DFMO) has been shown to decrease the …

Recently, two landmark reports on antiangiogenic therapy were published: Paez-Ribes and
colleagues (1) and Ebos and colleagues (2). The Board of the Metastasis Research Society …

Introduction Polyamines affect proliferation, differentiation, migration and apoptosis of cells,
indicating their potential as a target for cancer chemotherapy. Ornithine decarboxylase …

We have shown that inhibition of polyamine biosynthesis with α-difluoromethylornithine
(DFMO) reduces in vitro invasiveness and metastatic capacity of MDA-MB-435 breast cancer …

We have previously reported that inhibition of polyamine biosynthesis with α-
difluoromethylornithine (DFMO) reduces pulmonary metastasis from MDA-MB-435 human …