Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Evidence suggests that lifelong cumulative exposure to pesticides may generate lasting
toxic effects on the central nervous system and contribute to the development of Alzheimer's …

Pesticides are widely-used chemicals commonly applied in agriculture for the protection of
crops from pests. Depending on the class of pesticides, the specific substances may have a …

Neurodegenerative disorders are typically sporadic in nature in addition to usually
influenced through an extensive range of environmental factors, lifestyle, and genetic …

The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …

Environmental toxicants have been implicated in neurodegenerative diseases, and
pesticide exposure is a suspected environmental risk factor for Alzheimer's disease (AD) …

Mitochondria are critical for the provision of ATP for cellular energy requirements. Tissue
and organ functions are dependent on adequate ATP production, especially when energy …

Introduction Cholesterol homeostasis is critical for normal brain function. It is tightly
controlled by various biological elements. ATP-binding cassette transporter A1 (ABCA1) is a …

It has been demonstrated that peroxisome proliferator-activated receptor γ (PPARγ) can
regulate the transcription of its target gene, insulin-degrading enzyme (IDE), and thus …

Background: The interaction of aging-related, genetic, and environmental factors is thought
to contribute to the etiology of late-onset, sporadic Alzheimer's disease (AD). We previously …