Diamond‐Blackfan anemia (DBA) is an inherited disease characterized by pure erythroid
aplasia. Thirty percent (30%) of patients display malformations, especially of the hands, face …

Lipids are precisely distributed in the eukaryotic cell where they help to define organelle
identity and function, in addition to their structural role. Once synthesized, many lipids must …

Background Ab initio prediction of splice sites is an essential step in eukaryotic genome
annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene …

Muscle coenzyme Q 10 (CoQ 10 or ubiquinone) deficiency has been identified in more than
20 patients with presumed autosomal-recessive ataxia. However, mutations in genes …

Terpenoids are one of the largest and most diverse families of natural compounds. They are
heavily used in industry, and the trend is toward engineering modified microorganisms that …

Light, oxygen, or voltage (LOV) protein domains are present in many signaling proteins in
bacteria, archaea, protists, plants, and fungi. The LOV protein VIVID (VVD) of the filamentous …

Gene expression can be regulated at the level of initiation of protein biosynthesis via
structural elements present at the 5′ untranslated region of mRNAs. These folded mRNA …

Congenital stationary night blindness (CSNB) is a heterogeneous retinal disorder
characterized by visual impairment under low light conditions. This disorder is due to a …

Recognition of double-stranded RNA by Toll-like receptor 3 (TLR3) will increase the
production of cytokines and chemokines through transcriptional activation by the NF-κB …

Initiation of protein synthesis is a universally conserved event that requires initiation factors
IF1, IF2 and IF3 in prokaryotes. IF2 is a GTPase essential for binding initiator transfer RNA to …