Insects transmit the causative agents for such debilitating diseases as malaria, lymphatic
filariases, sleeping sickness, Chagas' disease, leishmaniasis, river blindness, Dengue, and …

Echinococcosis is a cosmopolitan zoonosis caused by adult or larval stages of cestodes
belonging to the genus Echinococcus (family Taeniidae). The two major species of medical …

Glutaredoxins catalyze glutathione-dependent thiol disulfide oxidoreductions via a GSH-
binding site and active cysteines. Recently a second human glutaredoxin (Grx2), which is …

Regulation of disulfide dithiol exchange has become increasingly important in our
knowledge of plant life. Initially discovered as regulators of light-dependent malate …

Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing
combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which …

NADPH-dependent thioredoxin reductases (NTR) are homodimeric enzymes that reduce
thioredoxins. Two genes encoding NADPH-dependent thioredoxin reductases (AtNTRA and …

Background The cestode Echinococcus granulosus-the agent of cystic echinococcosis, a
zoonosis affecting humans and domestic animals worldwide-is an excellent model for the …

Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …

Platyhelminth parasites are a major health problem in developing countries. In contrast to
their mammalian hosts, platyhelminth thiol-disulfide redox homeostasis relies on linked …

BACKGROUND: There are two, largely autonomous antioxidant pathways in many
organisms, one based on thioredoxin and one based on glutathione, with each pathway …