Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Inflammation in atherosclerosis—no longer a theory

P Libby - Clinical chemistry, 2021 - academic.oup.com
Background Inflammation links to atherosclerosis and its complications in various
experimental investigations. Animal studies have implicated numerous inflammatory …

From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection

PM Ridker - Circulation research, 2016 - Am Heart Assoc
Plasma levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP)
predict vascular risk with an effect estimate as large as that of total or high-density …

Inflammatory processes in cardiovascular disease: a route to targeted therapies

N Ruparelia, JT Chai, EA Fisher… - Nature reviews …, 2017 - nature.com
Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Inflammation in atherosclerosis

P Libby - Arteriosclerosis, thrombosis, and vascular biology, 2012 - Am Heart Assoc
Experimental work has elucidated molecular and cellular pathways of inflammation that
promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers …

[HTML][HTML] Type 2 diabetes mellitus: from a metabolic disorder to an inflammatory condition

I Hameed, SR Masoodi, SA Mir, M Nabi… - World journal of …, 2015 - ncbi.nlm.nih.gov
Diabetes mellitus is increasing at an alarming rate and has become a global challenge.
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …

A test in context: high-sensitivity C-reactive protein

PM Ridker - Journal of the American College of Cardiology, 2016 - jacc.org
The inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) adds prognostic
information on cardiovascular risk comparable to blood pressure or cholesterol. Values< 1, 1 …

Inflammation as a therapeutic target in atherosclerosis

MT Nguyen, S Fernando, N Schwarz, JTM Tan… - Journal of clinical …, 2019 - mdpi.com
Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …

Inflammation and atherosclerosis

P Libby, PM Ridker, A Maseri - Circulation, 2002 - Am Heart Assoc
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Atherosclerosis—an inflammatory disease

R Ross - New England journal of medicine, 1999 - Mass Medical Soc
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …