Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Cell signaling in response to an array of diverse stress stimuli converges on the
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …

The last decade has seen a dramatic increase in the use of small‐angle scattering for the
study of biological macromolecules in solution. The drive for more complete structural …

Protein kinase R (PKR) is a central component of the interferon antiviral defense pathway.
Upon binding double-stranded RNA (dsRNA), PKR undergoes autophosphorylation …

The double-stranded (ds) RNA-activated protein kinase, PKR, has a key role in the innate
immunity response to viral infection in higher eukaryotes. PKR contains an N-terminal …

Protein kinases are major drug targets, but the development of highly-selective inhibitors
has been challenging due to the similarity of their active sites. The observation of distinct …

The physiological link between circulating high density lipoprotein (HDL) levels and
cardiovascular disease is well-documented, albeit its intricacies are not well-understood. An …

The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-
driven proinflammatory gene expression in the macrophage—a response that is dependent …

Gephyrin is a trimeric protein involved in the final steps of molybdenum-cofactor (Moco)
biosynthesis and in the clustering of inhibitory glycine and GABAA receptors at postsynaptic …

The formation of cytoplasmic stress granules and the innate immune response are two
distinct cellular stress responses. Our study investigated the involvement of four innate …