The importance and need for an integrative mathematical modeling approach in the
biological and medical fields is currently well recognized. Such an approach is crucial in …

From an engineering perspective, many forms of heart disease can be thought of as a
reduction in biomaterial performance, in which the biomaterial is the tissue comprising the …

To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is
required. We introduce a novel screening system for drug-induced arrhythmogenic risk that …

The cellular basis of the T-wave morphology of surface ECG remains controversial in clinical
cardiology. We examined the effect of action potential duration (APD) distribution on T-wave …

Background The currently proposed criteria for identifying patients who would benefit from
cardiac resynchronization therapy (CRT) still need to be optimized. A multi-scale heart …

In this paper, we introduce a multiscale heart simulation method that integrates the three-
scale phenomena from the microscopic stochastic sarcomere kinetics to the macroscopic …

In the past decade, numerical methods for the computational biomechanics of blood flow
have progressed to overcome difficulties in diverse applications from cellular to organ …

Background The biomechanical simulation of the human respiratory system is expected to
be a useful tool for the diagnosis and treatment of respiratory diseases. Because the …

For treatment of complex congenital heart disease, computer simulation using a three-
dimensional heart model may help to improve outcomes by enabling detailed preoperative …

Background Recent studies, supported by advances in computer science, have successfully
simulated the excitation and repolarization processes of the heart, based on detailed cell …