There have been many ups and downs since the introduction of gene therapy as a
therapeutic modality for diseases. However, the journey of gene therapy has reached a …

Oncolytic viruses (OV) are an attractive prospect due to their dual attack mechanism of direct
cell lysis and potentiation of an antitumor immune response. Various oncolytic viral vectors …

Inherited retinal dystrophies (IRDs) affect an estimated 1 in every 2000 people, this
corresponding to nearly 2 million cases worldwide. Currently, 270 genes have been …

Glaucoma, a progressive optic neuropathy characterized by retinal ganglion cell
degeneration and visual field loss, is the leading cause of irreversible blindness worldwide …

Small molecule, peptide, and protein-based drugs have been developed over decades to
treat various diseases. The importance of gene therapy as an alternative to traditional drugs …

Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus
(DM), causing significant visual impairment worldwide. Current gold standards for retarding …

Introduction Recent technologies and new devices continue to be developed in vitreoretinal
surgeries, and they provide more details, enhance safety, improve surgeons' comfort, and …

This comprehensive review provides a thorough examination of inherited retinal diseases
(IRDs), encompassing their classification, genetic underpinnings, and the promising …

Rare genetic diseases are rare by themselves with prevalence of 1 in 25,000, but
collectively they are a significant cause of morbidity and mortality. Till date, collectively there …

Single-cell RNA sequencing (scRNA-seq) has enabled the identification of novel gene
signatures and cell heterogeneity in numerous tissues and diseases. Here we review the …