Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications
L Cao, J Wu, X Qu, J Sheng, M Cui, S Liu… - Journal of Experimental …, 2020 - Springer
Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …
Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors
X Sun, Y Peng, J Zhao, Z Xie, X Lei, G Tang - Bioorganic Chemistry, 2021 - Elsevier
Tumor cells mainly provide necessary energy and substances for rapid cell growth through
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …
Therapeutic potential of jasmonic acid and its derivatives
I Jarocka-Karpowicz, A Markowska - International Journal of Molecular …, 2021 - mdpi.com
A modern method of therapeutic use of natural compounds that would protect the body are
jasmonates. The main representatives of jasmonate compounds include jasmonic acid and …
jasmonates. The main representatives of jasmonate compounds include jasmonic acid and …
Room temperature synthesis of bioactive 1, 2, 4-oxadiazoles
1, 2, 4-Oxadiazole is an essential motif in drug discovery represented in many experimental,
investigational, and marketed drugs. This review covers synthetic methods that allow the …
investigational, and marketed drugs. This review covers synthetic methods that allow the …
Application of amidoximes for the heterocycles synthesis
In heterocyclic chemistry, amidoximes are mostly known as precursors for the synthesis of 1,
2, 4-oxadiazoles. Indeed, most of the works related to the use of amidoximes in the synthesis …
2, 4-oxadiazoles. Indeed, most of the works related to the use of amidoximes in the synthesis …
Advances in the Study of Hexokinase 2 (HK2) Inhibitors
S Wang, Y Zhuang, J Xu, Y Tong, X Li… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Purpose: The Warburg effect is an important metabolic feature of tumours, and hexokinase is
the first ratelimiting enzyme of the glycolytic pathway during tumour metabolism. Among …
the first ratelimiting enzyme of the glycolytic pathway during tumour metabolism. Among …
Circular RNAs and bladder cancer
Z Cai, H Li - OncoTargets and therapy, 2020 - Taylor & Francis
Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat
to human health. Circular RNAs (circRNAs) are members of a newly defined class of …
to human health. Circular RNAs (circRNAs) are members of a newly defined class of …
Immobilization of soybean lipoxygenase on nanoporous rice husk silica by adsorption: Retention of enzyme function and catalytic potential
P Ngin, K Cho, O Han - Molecules, 2021 - mdpi.com
Soybean lipoxygenase was immobilized on nanoporous rice husk silica particles by
adsorption, and enzymatic parameters of the immobilized protein, including the efficiency of …
adsorption, and enzymatic parameters of the immobilized protein, including the efficiency of …
Tumor Decelerating and Chemo-Potentiating Action of Methyl Jasmonate on a T Cell Lymphoma In Vivo: Role of Altered Regulation of Metabolism, Cell Survival …
Methyl jasmonate (MJ), a natural oxylipin, possesses a broad spectrum of antineoplastic
potential in vitro. However, its tumor growth impeding and chemo-potentiating action has not …
potential in vitro. However, its tumor growth impeding and chemo-potentiating action has not …
Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells
Change in the energy metabolism of cancer cells, which display significant differences
compared to normal cells, is a rising phenomenon in developing new therapeutic …
compared to normal cells, is a rising phenomenon in developing new therapeutic …