The role of resveratrol in liver disease: A comprehensive review from in vitro to clinical trials

C Izzo, M Annunziata, G Melara, R Sciorio, M Dallio… - Nutrients, 2021 - mdpi.com
Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders.
Its administration can significantly increase the survival rate after liver transplantation …

Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and antioxidative activities

S Chupradit, D Bokov, MY Zamanian… - Fundamental & …, 2022 - Wiley Online Library
Being the most essential organ in the body, the liver performs critical functions. Hepatic
disorders, such as alcoholic liver disease, hepatic steatosis, liver fibrosis, nonalcoholic fatty …

Effect of empagliflozin on thioacetamide-induced liver injury in rats: role of AMPK/SIRT-1/HIF-1α pathway in halting liver fibrosis

MA ElBaset, RS Salem, F Ayman, N Ayman, N Shaban… - Antioxidants, 2022 - mdpi.com
Hepatic fibrosis causes severe morbidity and death. No viable treatment can repair fibrosis
and protect the liver until now. We intended to discover the empagliflozin's (EMPA) …

Disease-associated regulation of non-coding RNAs by resveratrol: molecular insights and therapeutic applications

R Giordo, Z Wehbe, AM Posadino, GL Erre… - Frontiers in Cell and …, 2022 - frontiersin.org
There have been significant advances, particularly over the last 20 years, in the identification
of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease …

The involvement of TGF-β1/FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats

RF Abdel-Rahman, HM Fayed, GF Asaad, HA Ogaly… - PLoS …, 2021 - journals.plos.org
The objective of the current study is to investigate the effect of rice bran oil (RBO) on hepatic
fibrosis as a characteristic response to persistent liver injuries. Rats were randomly allocated …

Hepatoprotective effects of resveratrol on α-amanitin-induced liver toxicity in rats

A Gezer, H Ustundag, AS Mendil, G Bedir, L Duysak - Toxicon, 2024 - Elsevier
Objective The hepatoprotective effects of resveratrol against α-Amanitin (α-AMA)-induced
liver toxicity were investigated in an experimental rat model, focusing on oxidative stress …

Resveratrol contributes to the inhibition of liver fibrosis by inducing autophagy via the microRNA‑20a‑mediated activation of the PTEN/PI3K/AKT signaling pathway

L Zhu, Q Mou, Y Wang, Z Zhu… - … Journal of Molecular …, 2020 - spandidos-publications.com
Liver fibrosis (LF) is a healing response to wounds resulting in liver injury that can cause
liver failure or even cancer without functional prevention. Resveratrol (RSV) has been …

A comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids

X Pan, X Ma, Y Jiang, J Wen, L Yang… - Evidence‐based …, 2020 - Wiley Online Library
Liver fibrosis resulting from continuous long‐term hepatic damage represents a heavy
burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with …

Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis

H Wang, C Jiang, Y Yang, J Li, Y Wang, C Wang… - PeerJ, 2022 - peerj.com
This study is intended to explore the protective effects of resveratrol (RES) on iron overload-
induced liver fibrosis and its mechanism. Iron dextran (50 mg/kg) was injected …

Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth

Z Li, J Dong, M Wang, J Yan, Y Hu, Y Liu, Y Pan… - Molecular Medicine, 2022 - Springer
Background The altered gut microbiota is implicated in the pathogenesis of liver fibrosis.
Resveratrol is a candidate for the treatment of liver fibrosis, which could ameliorate the …