[HTML][HTML] NAC, NAC, Knockin'on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells

B Kalyanaraman - Redox Biology, 2022 - Elsevier
N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …

Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile—An Overlooked In Vitro Mechanism of Protection

P Mlejnek - Antioxidants, 2022 - mdpi.com
In laboratory experiments, many electrophilic cytotoxic agents induce cell death
accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) …

Visualization of biothiols and HClO in cancer therapy via a multi-responsive fluorescent probe

X Yang, J Liu, P Xie, X Han, D Zhang, Y Ye… - Sensors and Actuators B …, 2021 - Elsevier
Cancer is among the most important diseases threatening human life and health, and drug
chemotherapy is an effective method which can be used to treat cancer. Last several years …

[HTML][HTML] Understanding immune-modulatory efficacy in vitro

S Khatua, J Simal-Gandara, K Acharya - Chemico-Biological Interactions, 2022 - Elsevier
Boosting or suppressing our immune system represents an attractive adjunct in the
treatment of infections including SARS-CoV-2, cancer, AIDS, malnutrition, age related …

Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model

P Haloi, BS Lokesh, S Chawla, VB Konkimalla - Drug delivery, 2023 - Taylor & Francis
Rheumatoid arthritis (RA), a systemic autoimmune disease that dramatically affects patients'
quality of life. Given the intricacy of RA's pathophysiology, no single treatment can …

A dual-response NIR probe reveals positive correlation between biothiols and viscosity under cellular stress change

S Li, F Huo, Y Wen, C Yin - Chemical Communications, 2022 - pubs.rsc.org
A mitochondrial targeted NIR fluorescent probe NIR-NBD was designed and developed for
the detection of biothiols and viscosity. Furthermore, a positive correlation between the …

Reviewing the prospective pharmacological potential of isothiocyanates in fight against female-specific cancers

S Shoaib, FB Khan, MA Alsharif, MS Malik, SA Ahmed… - Cancers, 2023 - mdpi.com
Simple Summary Gynecological cancers are among the most commonly diagnosed cancers
in women globally. Despite advancements in diagnostics and treatments, these cancers …

The therapeutic effect of wasp venom (Vespa magnifica, Smith) and its effective part on rheumatoid arthritis fibroblast-like synoviocytes through modulating …

LL Ni, YH Che, HM Sun, B Wang, MY Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic inflammatory
disease that is related to the aberrant proliferation of fibroblast-like synoviocytes (FLS) …

Maackiain suppresses the development of cervical cancer via AMPK priming autophagy

J He, L Xiang, T Zhu, H Wang, Y Huang… - Journal of Pharmacy …, 2024 - academic.oup.com
Abstract Background Maackiain (Mac), a flavonoid analog isolated from Sophora flavescens,
exhibits neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic effects. It is not …

[HTML][HTML] Unveiling diagnostic and therapeutic strategies for cervical cancer: biomarker discovery through proteomics approaches and exploring the role of cervical …

A Jafari, M Farahani, M Abdollahpour-Alitappeh… - Frontiers in …, 2024 - frontiersin.org
Cervical cancer (CC) is a major global health problem and leading cause of cancer deaths
among women worldwide. Early detection through screening programs has reduced …