Regulation and function of transposable elements in cancer genomes
Over half of human genomic DNA is composed of repetitive sequences generated
throughout evolution by prolific mobile genetic parasites called transposable elements …
throughout evolution by prolific mobile genetic parasites called transposable elements …
LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs
The mechanisms that ensure developmental progression in the early human embryo remain
largely unknown. Here, we show that the family of long interspersed nuclear element 1 …
largely unknown. Here, we show that the family of long interspersed nuclear element 1 …
From the genome's perspective: Bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs
D Mangoni, A Mazzetti, F Ansaloni, A Simi… - …, 2024 - Wiley Online Library
Transposable elements (TEs) are mobile genomic elements constituting a big fraction of
eukaryotic genomes. They ignite an evolutionary arms race with host genomes, which in turn …
eukaryotic genomes. They ignite an evolutionary arms race with host genomes, which in turn …
PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease
S Schröder, U Fuchs, V Gisa, T Pena, DM Krüger… - Acta …, 2024 - Springer
Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic
maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of …
maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of …
Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic
element in both humans and mice, comprising almost 20% of each genome. L1s are …
element in both humans and mice, comprising almost 20% of each genome. L1s are …
LINE1 and its host: one cell's junk is another cell's treasure
LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of
pathologies. While improper de-repression of L1 transcription may drive disease …
pathologies. While improper de-repression of L1 transcription may drive disease …
Transposable elements acquire time-and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development
Gonadal sex determination in mice is a complex and dynamic process, which is crucial for
the development of functional reproductive organs. The expression of genes involved in this …
the development of functional reproductive organs. The expression of genes involved in this …
Retrotransposons in embryogenesis and neurodevelopment
MJ Talley, MS Longworth - Biochemical Society Transactions, 2024 - portlandpress.com
Retrotransposable elements (RTEs) are genetic elements that can replicate and insert new
copies into different genomic locations. RTEs have long been identified as 'parasitic genes' …
copies into different genomic locations. RTEs have long been identified as 'parasitic genes' …
[HTML][HTML] Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation
P Poltronieri - Exploration of Targeted Anti-tumor Therapy, 2024 - pmc.ncbi.nlm.nih.gov
Recently, new data have been added to the interaction between non-coding RNAs
(ncRNAs) and epigenetic machinery. Epigenetics includes enzymes involved in DNA …
(ncRNAs) and epigenetic machinery. Epigenetics includes enzymes involved in DNA …
Activation of Young LINE-1 Elements by CRISPRa
B Tong, Y Sun - International Journal of Molecular Sciences, 2023 - mdpi.com
Long interspersed element-1 (LINE-1; L1s) are mobile genetic elements that comprise
nearly 20% of the human genome. L1s have been shown to have important functions in …
nearly 20% of the human genome. L1s have been shown to have important functions in …