Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Laboratory conditions in biobehavioral experiments are commonly assumed to be
'controlled', having little impact on the outcome. However, recent studies have illustrated that …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

AIMS: Melatonin is a hormone synthesized principally in the pineal gland that has been
classically associated with endocrine actions. However, several lines of evidence suggest …

GOLOMBEK, DA, P. PÉVET AND DP CARDINALI. Melatonin effects on behavior: possible
mediation by the central GABAergic system. NEUROSCI BIOBEHAV REV 20 (3) 403–412 …

Background Central disinhibition is a mechanism involved in the physiopathology of
fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We …

The intensity of pain sensation exhibits marked day and night variations. Since the intensity
of pain perception is low during dark hours of the night when melatonin levels are high, this …

Recent evidence has demonstrated analgesic, anti-inflammatory, and anxiolytic properties
of melatonin. Taking into account that higher anxiety makes the control of postoperative pain …

Melatonin is a neurohormone secreted by epiphysis and extrapineal structures. It performs
several functions including chronobiotic, antioxidant, oncostatic, immune modulating …

Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects
are mediated by receptors while other, like cytoprotection, seem to depend on direct and …