C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established,. Here we report lifespan and healthspan …
J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and differentiation. There is increasing evidence of the therapeutic value of MSCs in various …
Y Wang, E Xu, PR Musich, F Lin - CNS neuroscience & …, 2019 - Wiley Online Library
Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria in aging and neurodegenerative …
J Miao, J Liu, J Niu, Y Zhang, W Shen, C Luo, Y Liu… - Aging cell, 2019 - Wiley Online Library
Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases. Aging is highly associated with the progression of renal fibrosis. Among several …
Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature …
T Yamamoto, Y Takabatake, A Takahashi… - Journal of the …, 2017 - journals.lww.com
Excessive fat intake contributes to the progression of metabolic diseases via cellular injury and inflammation, a process termed lipotoxicity. Here, we investigated the role of lysosomal …
R Schmitt, A Melk - Kidney international, 2017 - Elsevier
Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to the increasing incidence of acute kidney injury and chronic kidney disease. The aging …