Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Autophagy in kidney homeostasis and disease

C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Autophagy as a promoter of longevity: insights from model organisms

M Hansen, DC Rubinsztein, DW Walker - Nature reviews Molecular cell …, 2018 - nature.com
Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

ÁF Fernández, S Sebti, Y Wei, Z Zou, M Shi… - Nature, 2018 - nature.com
Autophagy increases the lifespan of model organisms; however, its role in promoting
mammalian longevity is less well-established,. Here we report lifespan and healthspan …

Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

Y Wang, E Xu, PR Musich, F Lin - CNS neuroscience & …, 2019 - Wiley Online Library
Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

J Miao, J Liu, J Niu, Y Zhang, W Shen, C Luo, Y Liu… - Aging cell, 2019 - Wiley Online Library
Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases.
Aging is highly associated with the progression of renal fibrosis. Among several …

Klotho, oxidative stress, and mitochondrial damage in kidney disease

J Donate-Correa, B Martín-Carro, JB Cannata-Andía… - Antioxidants, 2023 - mdpi.com
Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

High-fat diet–induced lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in the kidney

T Yamamoto, Y Takabatake, A Takahashi… - Journal of the …, 2017 - journals.lww.com
Excessive fat intake contributes to the progression of metabolic diseases via cellular injury
and inflammation, a process termed lipotoxicity. Here, we investigated the role of lysosomal …

[HTML][HTML] Molecular mechanisms of renal aging

R Schmitt, A Melk - Kidney international, 2017 - Elsevier
Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …