The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Why do we get the stress-related diseases we do? Why do some people have flare ups of
autoimmune disease, whereas others suffer from melancholic depression during a stressful …

Major depression, with its strikingly high prevalence, is the most common cause of disability
in communities of Western type, according to data of the World Health Organization. Stress …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Background: Dysregulated stress neurocircuits, caused by genetic and/or environmental
changes, underlie the development of many neuropsychiatric disorders. Corticotropin …

The stress–response is adaptive in the short-term, but it can be maladaptive if sustained
levels of its mediators are chronically maintained. Furthermore, not all individuals exposed …

When mammals, including man, are confronted with a stressful event, their core body
temperature rises, stress-induced hyperthermia. In mice, the stress-induced hyperthermia …

Two major and mutually interconnected brain systems are recruited during stress reaction.
One is the hypothalamic paraventricular nucleus (PVH) and the second is the extended …

Social stress is a major factor in the etiology of several psychopathologies, with individuals
greatly differing in vulnerability. The development of appropriate animal models of social …