Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases

V Mittelheisser, V Gensbittel, L Bonati, W Li… - Nature …, 2024 - nature.com
Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

The unique biomechanics of intermediate filaments–From single filaments to cells and tissues

U Rölleke, P Kumari, R Meyer, S Köster - Current Opinion in Cell Biology, 2023 - Elsevier
Together with actin filaments and microtubules, intermediate filaments (IFs) constitute the
eukaryotic cytoskeleton and each of the three filament types contributes very distinct …

Calcium supplementation of bioinks reduces shear stress-induced cell damage during bioprinting

L Fischer, M Nosratlo, K Hast, E Karakaya… - …, 2022 - iopscience.iop.org
During bioprinting, cells are suspended in a viscous bioink and extruded under pressure
through small diameter printing needles. The combination of high pressure and small …

Size-and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface

J Najafi, S Dmitrieff, N Minc - Proceedings of the National …, 2023 - National Acad Sciences
Many studies of cytoplasm rheology have focused on small components in the
submicrometer scale. However, the cytoplasm also baths large organelles like nuclei …

Navigating the biophysical landscape: how physical cues steer the journey of bone metastatic tumor cells

P Ouyang, B Cheng, X He, J Lou, X Li, H Guo, F Xu - Trends in Cancer, 2024 - cell.com
Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive.
The human skeletal system has unique physical properties, that are distinct from other …

High-throughput adjustable deformability cytometry utilizing elasto-inertial focusing and virtual fluidic channel

Z Zhou, C Ni, Z Zhu, Y Chen, Z Ni, N Xiang - Lab on a Chip, 2023 - pubs.rsc.org
Cell mechanical properties provide a label-free marker for indicating cell states and disease
processes. Although microfluidic deformability cytometry has demonstrated great potential …

Single-Cell Mechanics: Structural Determinants and Functional Relevance

M Urbanska, J Guck - Annual Review of Biophysics, 2024 - annualreviews.org
The mechanical phenotype of a cell determines its ability to deform under force and is
therefore relevant to cellular functions that require changes in cell shape, such as migration …

[HTML][HTML] Single-cell mechanical characterization in constriction-based cytometry

A Abarca-Ortega, B González-Bermúdez… - International Journal of …, 2024 - Elsevier
Mechanical characterization of suspended cells by constriction-based microfluidic devices
has currently various limitations related to the available analysis models. In this work, we …

Single-cell electro-mechanical shear flow deformability cytometry

J Chen, X Zou, DC Spencer, H Morgan - Microsystems & …, 2024 - nature.com
The complex structural and molecular features of a cell lead to a set of specific dielectric and
mechanical properties which can serve as intrinsic phenotypic markers that enable different …

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

C Handler, C Testi, G Scarcelli - Current Opinion in Cell Biology, 2024 - Elsevier
Recent research has highlighted the growing significance of the mechanical properties of
cells and tissues in the proper execution of physiological functions within an organism; …