The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However …

Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …

Objectives. These guidelines are based on a first edition that was published in 2004, and
have been edited and updated with the available scientific evidence up to October 2012 …

Family, twin, and adoption studies have been essential in defining the genetic epidemiology
of bipolar disorder over the past several decades. Family studies have documented that first …

Bipolar disorder is a mood disorder characterized by impairing episodes of mania and
depression. Twin studies have established that bipolar disorder is among the most heritable …

Objective: The authors sought to describe the emergent course of bipolar disorder in
offspring of affected parents subgrouped by parental response to lithium prophylaxis …

After decades of research, the mechanism of action of lithium in preventing recurrences of
bipolar disorder remains only partially understood. Lithium research is complicated by the …