Radical S-adenosylmethionine (SAM) enzymes use a site-differentiated [4Fe-4S] cluster and
SAM to initiate radical reactions through liberation of the 5′-deoxyadenosyl (5′-dAdo•) …

Enzymes that use a [4Fe‐4S] 1+ cluster plus S‐adenosyl‐l‐methionine (SAM) to initiate
radical reactions (radical SAM) form the largest enzyme superfamily, with over half a million …

A subset of natural products, such as polyketides and nonribosomal peptides, is
biosynthesized while tethered to a carrier peptide via a thioester linkage. Recently, we …

Enzymes of the radical S-adenosyl-l-methionine (radical SAM, RS) superfamily, the largest
in nature, catalyze remarkably diverse reactions initiated by H-atom abstraction. Glycyl …

Lanthipeptides are ribosomally synthesised and post-translationally modified peptides
containing lanthionine (Lan) and methyllanthionine (MeLan) residues that are formed by …

The radical S-adenosyl methionine (SAM) enzyme superfamily has widespread roles in
hydrogen atom abstraction reactions of crucial biological importance. In these enzymes …

Synthetic [Fe4S4] clusters with Fe–R groups (R= alkyl/benzyl) are shown to release organic
radicals on an [Fe4S4] 3+–R/[Fe4S4] 2+ redox couple, the same that has been proposed for …

OspD is a radical S-adenosyl-l-methionine (SAM) peptide epimerase that converts an
isoleucine (Ile) and valine (Val) of the OspA substrate to d-amino acids during biosynthesis …

Members of the radical S-adenosyl-l-methionine (SAM) enzyme superfamily initiate a broad
spectrum of radical transformations through reductive cleavage of SAM by a [4Fe–4S] 1+ …

OxsB is a B12-dependent radical SAM enzyme that catalyzes the oxidative ring contraction
of 2′-deoxyadenosine 5′-phosphate to the dehydrogenated, oxetane containing …