Chitin, a potential allergy-promoting pathogen-associated molecular pattern (PAMP), is a
linear polymer composed of N-acetylglucosamine residues which are linked by β-(1, 4) …

In the intestine, the mucosal immune system plays essential roles in maintaining
homeostasis between the host and microorganisms, and protecting the host from pathogenic …

The glycans displayed on mammalian cells can differ markedly from those on microbes.
Such differences could, in principle, be'read'by carbohydrate-binding proteins, or lectins. We …

Abstract Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein
belonging to the fibrinogen-related domain family. It has been localized to elastic fiber-rich …

MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic
fibers without a clearly defined role in elastic fiber assembly. In the present study, we …

The incidence of fungal infections has dramatically increased in recent years, in large part
due to increased use of immunosuppressive medications, as well as aggressive medical …

Complement represents a keystone to the innate immune system, with three activation
pathways that utilise foreign microbial pattern recognition as well as activation by the host's …

Renal fibrosis, which is characterized by excessive extracellular matrix (ECM) accumulation
in the renal tubulointerstitium, can lead to chronic kidney disease (CKD). The role of …

Objective—Arterial injury stimulates remodeling responses that, when excessive, lead to
stenosis. These responses are influenced by integrin signaling in vascular smooth muscle …

In the innate immune system, a variety of recognition molecules provide the first-line host
defense to prevent infection and maintain endogenous homeostasis. Ficolin is a soluble …