Galectin targeted therapy in oncology: Current knowledge and perspectives

K Wdowiak, T Francuz, E Gallego-Colon… - International journal of …, 2018 - mdpi.com
The incidence and mortality of cancer have increased over the past decades. Significant
progress has been made in understanding the underpinnings of this disease and …

Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer

V Karpisheh, A Nikkhoo, M Hojjat-Farsangi… - Prostaglandins & other …, 2019 - Elsevier
Although colon cancer is one of the most important triggers of cancer related mortality, a few
therapeutic options exist for this disease, including combination chemotherapy, anti-EGFR …

Targeting intracellular galectins for cancer treatment

R Nehmé, Y St-Pierre - Frontiers in Immunology, 2023 - frontiersin.org
Although considerable attention has been paid to the role of extracellular galectins in
modulating, positively or negatively, tumor growth and metastasis, we have witnessed a …

Functions and inhibition of galectin-7, an emerging target in cellular pathophysiology

NV Sewgobind, S Albers, RJ Pieters - Biomolecules, 2021 - mdpi.com
Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-
galactosides. It has been described to be involved in apoptosis, proliferation and …

[HTML][HTML] Decoding the multifaceted roles of galectins in self-defense

S Sato, J Iwaki, J Hirabayashi - Seminars in immunology, 2025 - Elsevier
In this review, we aim to explore the multifaceted roles of galectins in host defense from a
broader perspective, particularly regarding their functions when host integrity is …

Galectin-7 in epithelial homeostasis and carcinomas

T Advedissian, F Deshayes, M Viguier - International journal of molecular …, 2017 - mdpi.com
Galectins are small unglycosylated soluble lectins distributed both inside and outside the
cells. They share a conserved domain for the recognition of carbohydrates (CRD). Although …

Unraveling how tumor-derived galectins contribute to anti-cancer immunity failure

DJ Laderach, D Compagno - Cancers, 2021 - mdpi.com
Simple Summary This review compiles our current knowledge of one of the main pathways
activated by tumors to escape immune attack. Indeed, it integrates the current understanding …

Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs

NA Pinto, MC Abba, L Laporte, JM Pérez Sáez… - Cell Death & …, 2023 - nature.com
Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure
to sunlight ultraviolet (UV) radiation, climatic changes and clinical conditions associated with …

Galectins and Host–Pathogen Interactions: The roles in viral infections

SF Wang, HL Chen, FT Liu - Seminars in Immunology, 2024 - Elsevier
Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host–virus
interaction landscape. This review explores the multifaceted contributions of endogenous …

Towards a better understanding of the relationships between Galectin-7, p53 and MMP-9 during cancer progression

Y St-Pierre - Biomolecules, 2021 - mdpi.com
It has been almost 25 years since the discovery of galectin-7. This member of the galectin
family has attracted interest from many working in the cancer field given its highly restricted …