Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Purpose Triple-negative breast cancer (TNBC) is the most aggressive breast cancer
subgroup characterized by a high risk of resistance to chemotherapies and high relapse …

S-Adenosyl-l-methionine (SAM) analogs are adaptable tools for studying and therapeutically
inhibiting SAM-dependent methyltransferases (MTases). Some MTases play significant roles …

Approximately 50% of poor prognosis neuroblastomas arise due to MYCN over-expression.
We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 …

Epigenetically targeted therapeutic development, particularly for SAM-dependent
methylations of DNA, mRNA and histones has been proceeding rapidly for cancer …

Epithelial cells acquire mesenchymal characteristics during embryonic development, wound
healing, fibrosis, and in cancer in a processed termed epithelial‐to‐mesenchymal transition …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant disease with a low 5-year
overall survival rate. It is the third-leading cause of cancer-related deaths in the United …

Title. Novel PRMT5 Inhibitors Patent Publication Number. WO 2021/163344 A1 Publication
Date. August 19, 2021 Priority Application. US 62/975,258 Priority Date. February 12, 2020 …

Background Cholangiocarcinoma (CCA) is a very difficult-to-treat cancer. Chemotherapies
are little effective and response to immune checkpoint inhibitors is limited. Therefore, new …