Inhibition of Human Salivary and Pancreatic α-Amylase by Resveratrol Oligomers

R Visvanathan, DT Le, S Dhital, T Rali… - Journal of medicinal …, 2024 - ACS Publications
A key strategy to mitigate postprandial hyperglycemia involves inhibiting α-amylases, which
commence the starch digestion process in the gut. This study examined the inhibitory effects …

[HTML][HTML] Computer-aided design, synthesis, and biological evaluation of 4-chloro-N-(2-oxo-3-(2-pyridin-4-yl) hydrazineylidene) indolin-5yl) benzamide and 1-(4 …

VA Shu, DB Eni, MJM Tjegbe, I Tietjen, J Cassel… - The Microbe, 2024 - Elsevier
The emergence of the severe acute respiratory syndrome 2 (SARS-CoV-2) as a global threat
has driven the urgent need for the identification of bioactive molecules capable of controlling …

An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 fusion and M pro inhibitory agents: Synthesis, biological evaluation and computational …

AE Ehinak, MMM Lobe, CV Simoben, I Tietjen, DB Eni… - 2024 - researchsquare.com
Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of
biological activities, including antiviral activity. They are, therefore, recognized as privileged …