Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Sex differences in insomnia: from epidemiology and etiology to intervention

S Suh, N Cho, J Zhang - Current psychiatry reports, 2018 - Springer
Abstract Purpose of Review Insomnia is approximately 1.5 times more common in women
than in men. To date, research has advanced our knowledge about why women report …

Obstructive sleep apnea and psychiatric disorders: a systematic review

MA Gupta, FC Simpson - Journal of Clinical Sleep Medicine, 2015 - jcsm.aasm.org
Study Objectives: Obstructive sleep apnea (OSA) has been associated with psychiatric
pathology. Psychiatric comorbidity in OSA may affect patient quality of life and adherence to …

Personalized management approach for OSA

JC Carberry, J Amatoury, DJ Eckert - Chest, 2018 - Elsevier
OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment

DJ Eckert, MK Younes - Journal of Applied Physiology, 2014 - journals.physiology.org
Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally
important in restoring airflow and blood-gas disturbances at the end of obstructive sleep …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold

DJ Eckert, RL Owens, GB Kehlmann… - Clinical …, 2011 - portlandpress.com
Recent insights into sleep apnoea pathogenesis reveal that a low respiratory arousal
threshold (awaken easily) is important for many patients. As most patients experience stable …

Comorbid insomnia and obstructive sleep apnea: challenges for clinical practice and research

FS Luyster, DJ Buysse, PJ Strollo Jr - Journal of Clinical Sleep …, 2010 - jcsm.aasm.org
Study Objectives: To review studies examining the cooccurrence of insomnia and
obstructive sleep apnea (OSA), explore evidence for the effect of OSA therapy on insomnia …

Role of arousals in the pathogenesis of obstructive sleep apnea

M Younes - American journal of respiratory and critical care …, 2004 - atsjournals.org
Arousal is believed to be needed for upper airway opening in obstructive hypopneas–
apneas, without compelling evidence to support this notion. The association may be …

The male predisposition to pharyngeal collapse: importance of airway length

A Malhotra, Y Huang, RB Fogel, G Pillar… - American journal of …, 2002 - atsjournals.org
Obstructive sleep apnea is an important disorder because of both its prevalence and its
cardiovascular and neurocognitive sequelae. Despite the fact that male sex is a major risk …