Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …

Relaxin‐3 is a member of a superfamily of structurally‐related peptides that includes relaxin
and insulin‐like peptide hormones. Soon after the discovery of the relaxin‐3 gene, relaxin‐3 …

Recent advances in thick tissue clearing are enabling high resolution, volumetric
fluorescence imaging of complex cellular networks. Fluorescent proteins (FPs) such as GFP …

Relaxin‐3 has been proposed to modulate emotional–behavioural functions such as
arousal and behavioural activation, appetite regulation, stress responses, anxiety, memory …

Key points Relaxin‐3 is a stress‐responsive neuropeptide that acts at its cognate receptor,
RXFP3, to alter behaviours including feeding. In this study, we have demonstrated a direct …

Animal and clinical studies of gene-environment interactions have helped elucidate the
mechanisms involved in the pathophysiology of several mental illnesses including anxiety …

Binge eating is frequently stimulated by stress. The neuropeptide relaxin-3 (RLN3) and its
native receptor RXFP3 are implicated in stress and appetitive behaviors. We investigated …

Anxiety disorders are highly prevalent in modern society and better treatments are required.
Key brain areas and signaling systems underlying anxiety include prefrontal cortex …

Many physiological processes fluctuate throughout the day/night and daily fluctuations are
observed in brain and peripheral levels of several hormones, neuropeptides and …

Binge-eating disorder is the most common eating disorder. Various neuropeptides play
important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which …