Breast cancer is a common malignancy among women worldwide. Regardless of the
economic status of a country, breast cancer poses a burden in prevention, diagnosis and …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression,
and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate …

Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

Background Both aberrant alternative splicing and m6A methylation play complicated roles
in the development of pancreatic cancer (PC), while the relationship between these two …

Despite the availability of multiple human epidermal growth factor receptor 2–targeted
(HER2-targeted) treatments, therapeutic resistance in HER2+ breast cancer remains a …

Alternative splicing (AS) enables differential inclusion of exons from a given transcript,
thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play …

Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is
associated with altered expression, localization, and mutations of the components of the …

Triple-negative breast cancer (TNBC) is characterized by its aggressiveness and resistance
to cancer-specific transcriptome alterations. Alternative splicing (AS) is a major contributor to …