Major depressive disorder is a common psychiatric disorder associated with marked
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …

Importance The placebo effect in depression clinical trials is a substantial factor associated
with failure to establish efficacy of novel and repurposed treatments. However, the …

As the physiological impact of chronic stress is difficult to study in humans, naturalistic
stressors are invaluable sources of information in this area. This review systematically …

BackgroundDepression is considered to have the highest disability burden of all conditions.
Although treatment-resistant depression (TRD) is a key contributor to that burden, there is …

Treatment resistant depression (TRD) is associated with poor outcomes, but a consensus is
lacking in the literature regarding which compound represents the best pharmacological …

Development of new medications is a lengthy and costly process, and drug repositioning
might help to shorten the development cycle. We present a machine learning (ML) workflow …

Background Pharmacological augmentation is a recommended strategy for patients with
treatment-resistant depression. A range of guidelines provide advice on treatment selection …

Cognitive deficits are a core feature of serious mental illnesses such as schizophrenia,
major depressive disorder (MDD) and bipolar disorder (BD) and are a common cause of …