Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
AT1 receptor signaling pathways in the cardiovascular system
The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …
and pathophysiology has been well described whereas the detailed molecular mechanisms …
Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II
L Hunyady, KJ Catt - Molecular endocrinology, 2006 - academic.oup.com
Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli
SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
Caveolin-1 in tumor progression: the good, the bad and the ugly
Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
H Ohtsu, PJ Dempsey, S Eguchi - American Journal of …, 2006 - journals.physiology.org
A disintegrin and metalloprotease (ADAM) is a membrane-anchored metalloprotease
implicated in the ectodomain shedding of cell surface proteins, including the ligands for …
implicated in the ectodomain shedding of cell surface proteins, including the ligands for …
Angiotensin II and the development of insulin resistance: implications for diabetes
JA Olivares-Reyes, A Arellano-Plancarte… - Molecular and cellular …, 2009 - Elsevier
Angiotensin II (Ang II), the major effector hormone of the renin–angiotensin system (RAS),
has an important role in the regulation of vascular and renal homeostasis. Clinical and …
has an important role in the regulation of vascular and renal homeostasis. Clinical and …
ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium
SJ Fuller, K Sivarajah, PH Sugden - Journal of molecular and cellular …, 2008 - Elsevier
The epidermal growth factor (EGF) receptor (or ErbB1) and the related ErbB4 are
transmembrane receptor protein tyrosine kinases which bind extracellular ligands of the …
transmembrane receptor protein tyrosine kinases which bind extracellular ligands of the …
A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome
JJ Doyle, AJ Doyle, NK Wilson, JP Habashi, D Bedja… - Elife, 2015 - elifesciences.org
Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for
prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy …
prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy …
Regulation of angiotensin II receptors beyond the classical pathway
M Horiuchi, J Iwanami, M Mogi - Clinical Science, 2012 - portlandpress.com
The RAS (renin–angiotensin system) plays a role not only in the cardiovascular system,
including blood pressure regulation, but also in the central nervous system. AngII …
including blood pressure regulation, but also in the central nervous system. AngII …