▪ Abstract Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …

It is generally accepted that the principal roles of metallothionein lie in the detoxification of
heavy metals and regulation of the metabolism of essential trace metals. However, there is …

抄録 Metallothionein (MT) is a ubiquitous, cysteine-rich, metal-binding protein. MT synthesis
is induced by various stimuli such as cadmium, mercury, zinc, oxidative stress …

The antioxidant function of metallothionein (MT) was first suggested in the early 1980s.
Studies in vitro have revealed that MT reacts directly with reactive oxygen species, including …

Cisplatin, or cis-diamminedichloroplatinum (II)(CDDP), is an antineoplastic agent developed
in 1965 by Rosenberg et al.[70], who were studying the effects of electrolysis products from a …

Metallothionein (MT) may provide protection against doxorubicin-induced heart damage. To
test this hypothesis, a heart-specific promoter was used to drive the expression of human MT …

Cardiomyopathy induced by doxorubicin (DOX) has long been a major impediment of
clinical applications of this effective anticancer agent. Previous studies have shown that …

The treatment of alkylating cytotoxic drug cisplatin is often limited by high incidence rate of
resistance. In the present study, the potential involvement of the transcription factor Nrf2 in …

In this review an inventory is made of agents used to circumvent cis-
diamminedichloroplatinum (II)(CDDP) resistance in vitro and in vivo. Agents that affect …

Previous studies have shown that cardiac-specific metallothionein (MT)-overexpressing
transgenic mice are highly resistant to acute cardiotoxicity induced by doxorubicin (DOX), a …