A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors

AR Patten, CJ Fontaine, BR Christie - Frontiers in pediatrics, 2014 - frontiersin.org
Prenatal ethanol exposure (PNEE) has been linked to widespread impairments in brain
structure and function. There are a number of animal models that are used to study the …

Animal model systems for the study of alcohol teratology

TA Cudd - Experimental biology and medicine, 2005 - journals.sagepub.com
The incidence of fetal alcohol syndrome has not been declining even though alcohol has
been established as a teratogen and significant efforts have been made to educate women …

Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation

LL Wang, Z Zhang, Q Li, R Yang, X Pei, Y Xu… - Human …, 2009 - academic.oup.com
BACKGROUND microRNAs (miRNAs) play an important role in development and are
associated with birth defects. Data are scant on the role of miRNAs in birth defects arising …

Neonatal choline supplementation ameliorates the effects of prenatal alcohol exposure on a discrimination learning task in rats

JD Thomas, MH La Fiette, VRE Quinn… - Neurotoxicology and …, 2000 - Elsevier
Prenatal alcohol exposure can disrupt brain development and lead to a myriad of behavioral
alterations, including motor coordination deficits, hyperactivity, and learning deficits. There …

Animal models of drug addiction: Where do we go from here?

MC Olmstead - Quarterly Journal of Experimental …, 2006 - journals.sagepub.com
Compulsion and impulsivity are both primary features of drug addiction. Based on decades
of animal research, we have a detailed understanding of the factors (both environmental and …

Prenatal stress modifies behavior and hypothalamic-pituitary-adrenal function in female guinea pig offspring: effects of timing of prenatal stress and stage of …

A Kapoor, SG Matthews - Endocrinology, 2008 - academic.oup.com
Prenatal stress is associated with altered behavior and hypothalamic-pituitary-adrenal
(HPA) axis function postnatally. Recent studies suggest that these outcomes are dependent …

Impaired acquisition in the water maze and hippocampal long‐term potentiation after chronic prenatal ethanol exposure in the guinea‐pig

DP Richardson, ML Byrnes, JF Brien… - European Journal of …, 2002 - Wiley Online Library
In the hippocampus, the CA1 region is selectively vulnerable to the effects of chronic
prenatal ethanol exposure. In the guinea‐pig, the number of CA1 pyramidal cells is …

Does drug abuse beget drug abuse? Behavioral analysis of addiction liability in animal models of prenatal drug exposure

CJ Malanga, BE Kosofsky - Developmental Brain Research, 2003 - Elsevier
Prenatal exposure to drugs of abuse is the single largest preventable cause of
developmental compromise of American children today. In the clinical population, it is …

[HTML][HTML] Safety assessment for ethanol-based topical antiseptic use by health care workers: evaluation of developmental toxicity potential

A Maier, JL Ovesen, CL Allen, RG York… - Regulatory Toxicology …, 2015 - Elsevier
Ethanol-based topical antiseptic hand rubs, commonly referred to as alcohol-based hand
sanitizers (ABHS), are routinely used as the standard of care to reduce the presence of …

Pre-administration of G9a/GLP inhibitor during synaptogenesis prevents postnatal ethanol-induced LTP deficits and neurobehavioral abnormalities in adult mice

S Subbanna, BS Basavarajappa - Experimental neurology, 2014 - Elsevier
It has been widely accepted that deficits in neuronal plasticity underlie the cognitive
abnormalities observed in fetal alcohol spectrum disorder (FASD). Exposure of rodents to …