Over the past years, several preclinical in vitro and ex vivo models have been developed
that helped to understand some of the critical aspects of intestinal functions in health and …

Cell cultures are widely used in pharmaceutical, medical, food/nutrition and biological
sciences. In food and nutrition science, intestinal cell culture models of human origin are …

Enterotoxigenic Escherichia coli (ETEC) are an important diarrhea-causing pathogen and
are regarded as a global threat for humans and farm animals. ETEC possess several …

Synergic efforts in microfabrication processes, cells culture and tissue engineering promoted
extraordinary progress in Organ-on-Chip (OoC) technology, leading to the development of in …

LAMC2, as a unique chain in the Laminin 5 molecule, has been found to be associated with
malignant metastases in some cancers. However, the roles and mechanisms by which …

ABSTRACT Background: Persistent diarrhoea (PD), defined as diarrhoeal symptoms for
longer than 2 weeks, still forms a substantial disease burden in children under 5 years of …

Na+/H+ exchangers (NHEs) are expressed in virtually all human tissues and organs. Two
major tasks of those NHE isoforms that are located in plasma membranes are cell volume …

Cancer cells generate protons (H+) that are extruded to the extracellular medium mainly via
the Na+/H+ exchanger 1 (NHE1), which regulates intracellular pH (pHi) and cell …

Abstract l-Arginine is taken up via the cationic amino acid transporters (system y+/CATs) and
system y+ L in human umbilical vein endothelial cells (HUVECs). l-Arginine is the substrate …

NHE5, an isoform of the Na+/H+ exchanger (NHE) protein, is an ion-transporting membrane
protein that regulates intracellular pH and is highly expressed in colorectal adenocarcinoma …