Current advances on nanomaterials interfering with lactate metabolism for tumor therapy

Q Cheng, XL Shi, QL Li, L Wang, Z Wang - Advanced Science, 2024 - Wiley Online Library
Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …

An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors

MK Temre, A Kumar, SM Singh - Frontiers in Pharmacology, 2022 - frontiersin.org
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …

Targeting the Warburg Effect in Cancer: Where Do We Stand?

I Barba, L Carrillo-Bosch, J Seoane - International Journal of Molecular …, 2024 - mdpi.com
The Warburg effect, characterized by the preferential conversion of glucose to lactate even
in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of …

Therapeutic implications of the metabolic changes associated with BRAF inhibition in melanoma

AW Loftus, M Zarei, H Kakish, O Hajihassani… - Cancer treatment …, 2024 - Elsevier
Melanoma metabolism can be reprogrammed by activating BRAF mutations. These
mutations are present in up to 50% of cutaneous melanomas, with the most common being …

Unveiling tumor immune evasion mechanisms: abnormal expression of transporters on immune cells in the tumor microenvironment

L Chen, Y Wang, Q Hu, Y Liu, X Qi, Z Tang… - Frontiers in …, 2023 - frontiersin.org
The tumor microenvironment (TME) is a crucial driving factor for tumor progression and it
can hinder the body's immune response by altering the metabolic activity of immune cells …

Glycolysis, The Sweet Appetite of the Tumour Microenvironment

Z Kooshan, L Cárdenas-Piedra, J Clements, J Batra - Cancer Letters, 2024 - Elsevier
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis
and lactate production, even in the presence of sufficient oxygen-a phenomenon known as …

Functional importance of glucose transporters and chromatin epigenetic factors in Glioblastoma Multiforme (GBM): possible therapeutics

S Chamarthy, JR Mekala - Metabolic Brain Disease, 2023 - Springer
Glioblastoma Multiforme (GBM) is an aggressive brain cancer affecting glial cells and is
chemo-and radio-resistant. Glucose is considered the most vital energy source for cancer …

Blockade of phosphodiesterase 5 by sildenafil reduces tumor growth and potentiates tumor‐killing ability of cisplatin in vivo against T cell lymphoma: Implication of …

SG Rawat, RK Tiwari, A Kumar - Environmental Toxicology, 2024 - Wiley Online Library
In the past years, PDE5 has emerged as a promising therapeutic target for many cancers
due to its highly upregulated expression. Interestingly, a recent in vitro study by our group …

ALMS1-IT1: A Key Player in the Novel Disulfidptosis-Related LncRNA Prognostic Signature for Head and Neck Squamous Cell Carcinoma

XY Sun, M Xiao, M Fu, Q Gao, RF Li, J Wang, SL Li… - Biomolecules, 2024 - mdpi.com
Disulfidptosis is a newly discovered form of programmed cell death that is induced by
disulfide stress. It is closely associated with various cancers, including head and neck …

Role of SFRP5 in Non-Small Cell Lung Cancer and Its Correlation with SUV of 18F-FDG PET-CT

N Zhang, T Bai, Y Jiang, K Zhu, L Yao, J Ji… - Journal of Investigative …, 2024 - Taylor & Francis
Aim: This study aimed to evaluate the relationship between secreted frizzled-related protein
5 (SFRP5) expression and fluorine 18-fluoro-deoxyglucose (18 F-FDG) uptake imaged with …